Selective Androgen Receptor Modulators: Latest Experience and Scientific Plans

Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors based on each SARM’s chemical structure. Consequently, SARMs lead to anabolic cellular activity while avoiding many of the negative effects of currently available anabolic steroids. SARMs have already been studied in the treatments for breast cancer and cachexia and also have also been used as performance-enhancing agents. Here, we evaluate and summarize the present literature on SARMs.

Aim
Presenting the history, mechanisms, current and potential clinical applications, along with risks and benefits of SARMs.

Methods
A literature review was performed in MEDLINE with all the terms selective androgen receptor modulator, hypogonadism, cachexia, breast cancer, benign prostatic hyperplasia, libido, and muscle. Both research and scientific studies were included.

Main Outcome Measure
To accomplish a review of peer-reviewed literature.

Results
Nevertheless, there are presently no U.S. Food and Drug Agency-approved indications for SARMs, investigators are checking out the potential ways to use these compounds. Investigation has focused on the pharmacokinetics and pharmacodynamics of the agents, demonstrating good availability using a paucity of drug interactions. Early clinical tests have demonstrated potential purposes of SARMs in the treatment of cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and breast cancers, with good success.

Conclusion
SARMs have numerous possible clinical applications, with promise to the safe use in treating cachexia, BPH, hypogonadism, cancer of the breast, and prostate type of cancer.

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