Selective Androgen Receptor Modulators: Latest Information and Medical Uses

Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors determined by each SARM’s chemical structure. Because of this, SARMs result in anabolic cellular activity while avoiding many of the side effects of currently available steroids. SARMs are already studied within the treatment of breast cancer and cachexia and still have been used as performance-enhancing agents. Here, we evaluate and summarize the actual literature on SARMs.

Aim
Presenting the history, mechanisms, current and potential clinical applications, and also risks and great things about SARMs.

Methods
A literature review was performed in MEDLINE while using terms selective androgen receptor modulator, hypogonadism, cachexia, cancers of the breast, benign prostatic hyperplasia, libido, and lean body mass. Both investigation and clinical tests were included.

Main Outcome Measure
To perform a review of peer-reviewed literature.

Results
Though there are no U.S. Drug and food Agency-approved indications for SARMs, investigators are going through the potential ways to use these compounds. Preliminary research has dedicated to the pharmacokinetics and pharmacodynamics of the agents, demonstrating good availability having a paucity of drug interactions. Early clinical tests have demonstrated potential uses for SARMs from the treating cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and breast cancers, with positive results.

Conclusion
SARMs have some of possible clinical applications, with promise for the safe use within the management of cachexia, BPH, hypogonadism, cancer of the breast, and prostate cancer.

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